Warfarin alone or with aspirin was superior to aspirin alone after acute myocardial infarction but increased bleeding.

Main results Analysis was by intention to treat. Both warfarin groups had lower rates for the main composite measure, nonfatal reinfarction, and thromboembolic stroke than the aspirin alone group (table); the 2 warfarin groups did not differ for these outcomes. The 3 groups did not differ for overall mortality. Both warfarin groups had higher rates for nonfatal major bleeding episodes than the aspirin alone group (table); the 2 warfarin groups did not differ for this outcome.